The State of the PFAS report and the Risk Management Scope document were released for public comments during a time when Bill S-5 (Strengthening Environmental Protection for a Healthier Canada Act) received Royal Assent on June 13, 2023. The updated CEPA includes substantial changes to the listing of toxic substances under Schedule 1 of CEPA. The findings of the State of PFAS concluding PFAS as a class meet more than one criterion under section 64 are expected to be relevant due to the changes in CEPA. A listing of PFAS as a class under CEPA should be made in Part 1 of Schedule 1 of CEPA. Based on the body of evidence collected in the State of the PFAS report demonstrating the ecological toxicity and associated impacts of PFAS as a class to health, it is critical that PFAS as a class be given the full scope of regulatory measures, particularly with a focus on prohibition, that is permitted under CEPA.